ReferenceID 5481
Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways
Cancer Cell Int
BACKGROUND: Cervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, i
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5481
- Evidence Id
- 22071
- Core Evidence Id
- 22071
- Source Reference Id
- 4203
- Herb2 Reference Id
- HBREF005000
- Subject Paper Key
- HBIN029922_33849528
- Pubmed Id
- 33849528
- Doi
- 10.1186/s12935-021-01910-2
- Paper Title
- Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways
- Paper Abstract
- BACKGROUND: Cervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, including cervical cancer. The study aimed to reveal the antitumor effects and the possible underlying mechanism of ICA in U14 tumor-bearing mice and SiHa cells. METHODS: The antitumor effects of ICA were investigated in vivo and in vitro. The expression of TLR4/MyD88/NF-kappaB and Wnt/beta-catenin signaling pathways were evaluated. RESULTS: We found that ICA significantly suppressed tumor tissue growth and SiHa cells viability in a dose-dependent manner. Also, ICA enhanced the anti-tumor humoral immunity in vivo. Moreover, ICA significantly improved the composition of the microbiota in mice models. Additionally, the results clarified that ICA significantly inhibited the migration, invasion capacity, and expression levels of TGF-beta1, TNF-alpha, IL-6, IL-17A, IL-10 in SiHa cells. Meanwhile, ICA was revealed to promote the apoptosis of cervical cancer cells by down-regulating Ki67, survivin, Bcl-2, c-Myc, and up-regulating P16, P53, Bax levels in vivo and in vitro. For the part of mechanism exploration, we showed that ICA inhibits the inflammation, proliferation, migration, and invasion, as well as promotes apoptosis and immunity in cervical cancer through impairment of TLR4/MyD88/NF-kappaB and Wnt/beta-catenin pathways. CONCLUSIONS: Taken together, ICA could be a potential supplementary agent for cervical cancer treatment.
- Journal
- Cancer Cell Int
- Publish Year
- 2021
- Experiment Subject
- mouse; siha cells; women
- Experiment Type
- Cell Experiment
- Phenotype Related
- Gynecology Tumor; Cancers; Tumor; Cervical Cancer
- Paper Title Cn
- Paper Title En
- Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways
- Bilingual Status
- semi_complete