ReferenceID 5479
Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs
Mol Ther Nucleic Acids
Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, the underl
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5479
- Evidence Id
- 22069
- Core Evidence Id
- 22069
- Source Reference Id
- 4200
- Herb2 Reference Id
- HBREF004997
- Subject Paper Key
- HBIN029922_33510936
- Pubmed Id
- 33510936
- Doi
- 10.1016/j.omtn.2020.11.021
- Paper Title
- Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs
- Paper Abstract
- Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, the underlying mechanism remains unclear. In this study, we explored the molecular mechanism underlying the protective function of icariin in oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells. H19, a long non-coding RNA, was identified to be downregulated in the background of the oxidized low-density lipoprotein-induced endothelial-mesenchymal transition in human umbilical vein endothelial cells. Icariin upregulated H19 expression and inhibited the transformation of endothelial cells into interstitial cells. Overexpression of H19 affected endothelial-mesenchymal transition in oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells, whereas H19 knockdown reversed endothelial protective effects of icariin and reduced human umbilical vein endothelial cell migration. Knockdown of H19 significantly downregulated oxidized low-density lipoprotein-induced E74-like factor 5 and upregulated miR-148b-3p, which was reversed by icariin. Thus, icariin may play a protective role in atherosclerosis, and H19 may be a potential therapeutic target.
- Journal
- Mol Ther Nucleic Acids
- Publish Year
- 2020
- Experiment Subject
- human; oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Atherosclerosis; Cardio-cerebrovascular Diseases
- Paper Title Cn
- Paper Title En
- Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs
- Bilingual Status
- semi_complete