ReferenceID 5456
Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway
Chem Biol Interact
Tumor angiogenesis, which may be affected by microenvironmental inflammation and promotes tumor development and metastasis, is one of the key reasons contributing to increased mortality. The goal of this study is to inve
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Record Fields
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- Reference Id
- 5456
- Evidence Id
- 22046
- Core Evidence Id
- 22046
- Source Reference Id
- 4167
- Herb2 Reference Id
- HBREF004964
- Subject Paper Key
- HBIN029531_36470525
- Pubmed Id
- 36470525
- Doi
- 10.1016/j.cbi.2022.110295
- Paper Title
- Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway
- Paper Abstract
- Tumor angiogenesis, which may be affected by microenvironmental inflammation and promotes tumor development and metastasis, is one of the key reasons contributing to increased mortality. The goal of this study is to investigate how lignin analogs, specifically honokiol (HNK), block angiogenesis induced by the inflammatory milieu of lung cancer. The human lung cancer cell lines A549 and H460 were treated with HNK. Interleukin-1 was employed to mimic an inflammatory tumor microenvironment. Findings demonstrated that HNK drastically decreased the cell viability of A549 and H460 cells. In A549 and H460 cells, HNK also reduced the production of vascular endothelial growth factor (VEGF), the most important marker of tumor angiogenesis. Signal pathway studies revealed that HNK blocked the NF-κB signaling pathway. This effect, in turn, prevented the expression of VEGF by inhibiting the NF-κB signaling pathway. Human umbilical vein endothelial cells (HUVECs) from A549-conditioned medium cultures were subjected to HNK treatment, which decreased tubulogenesis, horizontal and vertical migration, and cell proliferation in HUVECs. Overall, HNK inhibited the NF-κB pathway. This effect resulted in the downregulation of VEGF, thus reducing the viability and angiogenesis of human lung cancer cell lines. In A549 cell xenografts, HNK decreased VEGF expression, tumor angiogenesis, and tumor development. Our research shows that HNK is a potential antiangiogenic molecule for the treatment of lung cancer.
- Journal
- Chem Biol Interact
- Publish Year
- 2022
- Experiment Subject
- human; a549 cell xenografts; a549-conditioned medium cultures; h460 cells; human lung cancer cell lines; human umbilical vein endothelial cells; huvecs
- Experiment Type
- Cell Experiment
- Phenotype Related
- Lung Cancer; Tumor
- Paper Title Cn
- Paper Title En
- Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway
- Bilingual Status
- semi_complete