ReferenceID 5431
Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats
Life Sci
AIMS: Doxorubicin (Dox) is routinely used for breast cancer treatment but toxicity and drug resistance limit its use. The objective of the study was to investigate the protective effects of hesperidin alone and in combin
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- Reference Id
- 5431
- Evidence Id
- 22021
- Core Evidence Id
- 22021
- Source Reference Id
- 4113
- Herb2 Reference Id
- HBREF004910
- Subject Paper Key
- HBIN029196_34530017
- Pubmed Id
- 34530017
- Doi
- 10.1016/j.lfs.2021.119957
- Paper Title
- Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats
- Paper Abstract
- AIMS: Doxorubicin (Dox) is routinely used for breast cancer treatment but toxicity and drug resistance limit its use. The objective of the study was to investigate the protective effects of hesperidin alone and in combination with doxorubicin against experimentally induced breast cancer in female rats. METHODS: Breast cancer (BC) was induced by administration of 7,12-dimethylbenz(a)anthracene (DMBA) through subcutaneous injection into the 3rd right mammary gland of female Wistar rats. Hesperidin (Hes) pretreated groups were started with Hes (200 mg/kg) two weeks prior to DMBA induction. Animals were randomly divided into nine groups namely vehicle control, DMBA-induced, Dox 4 mg/kg, Dox 2 mg/kg, Hes (200 mg/kg), Hes (200 mg/kg) plus Dox 4 mg/kg treated groups and Hes pretreated groups treated with DMBA, Dox 4 mg/kg and Dox 2 mg/kg. KEY FINDINGS: Hes pretreated groups showed reduced tumor occurrence, tumor volume and increased survival rate as compared to DMBA-induced group of animals. Hes pretreated animals treated with Dox 4 mg/kg and 2 mg/kg exhibited significant reduction in malondialdehyde and improvement in levels of glutathione and inflammatory markers like IL-6, TNF-alpha, NF-kappaB, IFN-gamma as compared to Dox 4 mg/kg and 2 mg/kg treated animals. Histopathology and Ki67 expression depicted better control of tumor with Hes pretreatment groups as compared to DMBA-induced. Histopathology of vital organs of Hes pretreated groups treated with Dox revealed lesser toxicity than Dox treated groups. SIGNIFICANCE: Hesperidin possesses protective effect against experimentally induced breast cancer in female rats that appears to be related to attenuation of Ki67 expression.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Breast Cancer; Tumor
- Paper Title Cn
- Paper Title En
- Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats
- Bilingual Status
- semi_complete