ReferenceID 5421
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study
Food Funct
Osteoarthritis (OA), a progressive joint disorder, is principally characterized by the degeneration and destruction of articular cartilage. Previous research studies demonstrated that inflammation and ECM degradation pla
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5421
- Evidence Id
- 22011
- Core Evidence Id
- 22011
- Source Reference Id
- 4093
- Herb2 Reference Id
- HBREF004890
- Subject Paper Key
- HBIN029190_32159191
- Pubmed Id
- 32159191
- Doi
- 10.1039/c9fo02552a
- Paper Title
- The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study
- Paper Abstract
- Osteoarthritis (OA), a progressive joint disorder, is principally characterized by the degeneration and destruction of articular cartilage. Previous research studies demonstrated that inflammation and ECM degradation play a major role in OA development. Hesperetin, the aglycone of neohesperidin found in the peel of Citrus aurantium L. (Rutaceae), demonstrated in several studies potential anti-inflammatory activity in a variety of diseases. However, the mechanisms by which hesperetin plays a protective role in osteoarthritis (OA) are not completely understood. In this study, we found the anti-inflammatory effects of hesperetin in the progression of OA in both in vitro and in vivo experiments. In vitro, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by hesperetin. Moreover, hesperetin down-regulated the IL-1beta-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) while up-regulating collagen type II and aggrecan. Mechanistically, we revealed that hesperetin suppressed nuclear factor kappa B (NF-kappaB) signaling by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in IL-1beta-induced chondrocytes. Hesperetin-induced repression of OA development is shown using a DMM model. Taken together, our findings suggest that hesperetin may be a novel potential therapeutic agent for repressing the development of OA.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- il-1beta-induced chondrocytes
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Osteoarthritis; Tumor; Joint Disorder; Degeneration And Destruction Of Articular Cartilage
- Paper Title Cn
- Paper Title En
- The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study
- Bilingual Status
- semi_complete