ReferenceID 5382
Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration
Antioxidants (Basel)
Gossypetin (GTIN), known as 3,5,7,8,3',4'-hexahydroxyflavone, has been demonstrated to exert anti-atherosclerotic potential against apoptotic injury in oxidized low-density lipoprotein-incubated endothelial cells, and at
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Record Fields
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- Reference Id
- 5382
- Evidence Id
- 21972
- Core Evidence Id
- 21972
- Source Reference Id
- 4016
- Herb2 Reference Id
- HBREF004813
- Subject Paper Key
- HBIN028340_34572989
- Pubmed Id
- 34572989
- Doi
- 10.3390/antiox10091357
- Paper Title
- Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration
- Paper Abstract
- Gossypetin (GTIN), known as 3,5,7,8,3',4'-hexahydroxyflavone, has been demonstrated to exert anti-atherosclerotic potential against apoptotic injury in oxidized low-density lipoprotein-incubated endothelial cells, and atherosclerotic lesions of cholesterol-fed rabbits. However, the effect and underlying mechanism of GTIN on abnormal vascular smooth muscle cells (VSMCs) proliferation and migration, a major event in the pathogenesis of atherosclerosis, is still unknown. In this study, non-cytotoxic doses of GTIN abolished the VSMCs A7r5 proliferation and cell-cycle S phase distribution. The GTIN-arrested G0/G1 phase might be performed by increasing the expressions of phosphorylated p53 and its downstream molecules that inhibit the activation of cyclin E/cyclin-dependent kinase (cdk)-2, blocking retinoblastoma protein (Rb) phosphorylation and the subsequent dissociation of Rb/transcription factor E2F1 complex. In addition, the results indicated that GTIN inhibited VSMCs wound-healing and migratory abilities through reducing matrix metalloproteinase (MMP)-9 activity and expression, as well as down-regulating protein kinase B (PKB)/nuclear factor-kappaB (NF-kappaB) signaling. GTIN also revealed potential in diminishing reactive oxygen species (ROS) generation. These findings suggested the inhibitory effects of GTIN on VSMCs dysfunction could likely lead to the containment of atherosclerosis and other cardiovascular illness.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2021
- Experiment Subject
- oxidized low-density lipoprotein-incubated endothelial cells; rabbit
- Experiment Type
- Cell Experiment
- Phenotype Related
- Atherosclerotic Lesions; Vsmcs Dysfunction; Cardiovascular Illness; Atherosclerosis; Retinoblastoma
- Paper Title Cn
- Paper Title En
- Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration
- Bilingual Status
- semi_complete