ReferenceID 5337
The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats
Antioxidants (Basel)
Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota
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Record Fields
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- Reference Id
- 5337
- Evidence Id
- 21927
- Core Evidence Id
- 21927
- Source Reference Id
- 3931
- Herb2 Reference Id
- HBREF004728
- Subject Paper Key
- HBIN027527_35453317
- Pubmed Id
- 35453317
- Doi
- 10.3390/antiox11040632
- Paper Title
- The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats
- Paper Abstract
- Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota as the main mechanism for improving metabolic aberrations. Male Sprague Dawley rats were divided into normal diet (ND)- and HFD-fed animals and treated with geraniin and an enriched extract of geraniin (GEE). We observed that 5 mg geraniin and 115 mg GEE supplementation significantly attenuated glucose intolerance, lipopolysaccharide-binding protein, total cholesterol, triacylglyceride, and low-density lipoprotein; improved insulin sensitivity; and significantly increased adiponectin and hepatic PPARĪ± expression. Although geraniin and GEE did not significantly alter the gut microbial composition, we found an increment in the relative abundance of a few butyrate producers such as Alloprevotella , Blautia , Lachnospiraceae NK4A136 group , and Clostridium sensu stricto 1 . Geraniin and its enriched extract's ability to ameliorate metabolic syndrome parameters while positively affecting the growth of butyrate-producing bacteria suggests its potential prebiotic role.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2022
- Experiment Subject
- clostridium; sprague-dawley rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Metabolic Syndrome
- Paper Title Cn
- Paper Title En
- The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats
- Bilingual Status
- semi_complete