ReferenceID 5334
Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats
Life Sci
AIMS: This study aimed to examine whether gentiopicroside (GPS) could exert hepatoprotective effects on leflunomide (LEF)- and/or methotrexate (MTX)-treated arthritic rats through anti-inflammatory and antioxidant pathwa
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Record Fields
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- Reference Id
- 5334
- Evidence Id
- 21924
- Core Evidence Id
- 21924
- Source Reference Id
- 3924
- Herb2 Reference Id
- HBREF004721
- Subject Paper Key
- HBIN027510_33130083
- Pubmed Id
- 33130083
- Doi
- 10.1016/j.lfs.2020.118689
- Paper Title
- Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats
- Paper Abstract
- AIMS: This study aimed to examine whether gentiopicroside (GPS) could exert hepatoprotective effects on leflunomide (LEF)- and/or methotrexate (MTX)-treated arthritic rats through anti-inflammatory and antioxidant pathways. MAIN METHODS: We observed the external symptoms of joints, analysed serum indicators, measured haematological parameters and mRNA levels, and performed HE staining. KEY FINDINGS: LEF and/or MTX combined with GPS ameliorated oxidative stress by increasing the mRNA levels of the antioxidant gene Nrf2, GCLC, HO-1, and NQO1, increasing the antioxidant enzymes superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT), reducing the oxidant substance malondialdehyde (MDA), reducing the inflammatory response by decreasing the mRNA levels of NF-kappaB, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), and inhibiting the secretion of the pro-inflammatory cytokines TNFalpha, IL-6, IL-1beta and reducing C-reactive protein (CRP), as well as alleviating the external symptoms of arthritis. SIGNIFICANCE: These results show that GPS plays an antioxidant and anti-inflammatory role in LEF- and/or MTX-treated arthritic rats by affecting the Nrf2 and NF-kappaB signalling pathways, thus exerting hepatoprotective effects.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Arthritic; Arthritis
- Paper Title Cn
- Paper Title En
- Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats
- Bilingual Status
- semi_complete