ReferenceID 529
Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
Cancer Lett
In this study, we investigated the mechanism of brucine in tumor angiogenesis. We found that brucine inhibits VEGF-induced cell proliferation, chemotactic motility, and the formation of capillary-like structures in HUVEC
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 529
- Evidence Id
- 17119
- Core Evidence Id
- 17119
- Source Reference Id
- 1022
- Herb2 Reference Id
- HBREF001746
- Subject Paper Key
- HBIN018923_23348691
- Pubmed Id
- 23348691
- Doi
- 10.1016/j.canlet.2013.01.012
- Paper Title
- Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
- Paper Abstract
- In this study, we investigated the mechanism of brucine in tumor angiogenesis. We found that brucine inhibits VEGF-induced cell proliferation, chemotactic motility, and the formation of capillary-like structures in HUVECs in a dose-dependent manner. Brucine suppresses VEGF- induced p-VEGFR2 kinase activity and inhibits neovascularization in vivo. Brucine inhibits the downstream protein kinases of VEGFR2, including Src, FAK, ERK, AKT and mTOR. And further downregulates levels of VEGF, NO, IL-6, IL-8, TNF-α and IFN-γ in HUVECs. Taken together, our study suggests that brucine potently suppresses angiogenesis by targeting VEGFR2 activation and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies.
- Journal
- Cancer Lett
- Publish Year
- 2013
- Experiment Subject
- Experiment Type
- Others
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
- Bilingual Status
- semi_complete