ReferenceID 5239
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence
Front Pharmacol
Idiopathic pulmonary fibrosis is an aging-associated disease, satisfactory therapies are not yet available. Accelerated senescence of alveolar epithelial cells plays an important part in Idiopathic pulmonary fibrosis pat
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Record Fields
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- Reference Id
- 5239
- Evidence Id
- 21829
- Core Evidence Id
- 21829
- Source Reference Id
- 3750
- Herb2 Reference Id
- HBREF004547
- Subject Paper Key
- HBIN026506_33381023
- Pubmed Id
- 33381023
- Doi
- 10.3389/fphar.2020.553690
- Paper Title
- Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence
- Paper Abstract
- Idiopathic pulmonary fibrosis is an aging-associated disease, satisfactory therapies are not yet available. Accelerated senescence of alveolar epithelial cells plays an important part in Idiopathic pulmonary fibrosis pathogenesis. Fisetin (FIS) is a natural non-toxic flavonoid, which has many pharmacological functions. However, the role of FIS in pulmonary fibrosis has not been established. In this study, we found that FIS treatment apparently alleviated BLM-induced weight loss, inflammatory cells infiltration, inflammatory factors expression, collagen deposition and alveolar epithelial cell senescence, along with AMPK activation and the down regulation of NF-kappaB and TGF-beta/Smad3 in vivo. In vitro, FIS administration significantly inhibited the senescence of alveolar epithelial cells and senescence-associated secretory phenotype, followed by reduced transdifferentiation of fibroblasts to myofibroblasts as well as collagen deposition in fibroblasts, which was blocked by an AMPK inhibitor, Compound C. Together, these results suggest that FIS can alleviate the development of BLM-induced pulmonary fibrosis, which is related to the inhibition of TGF-beta/Smad3 signaling and the reduction of alveolar epithelium cell senescence by regulating AMPK/NF-kappaB signaling pathway. FIS may be a promising candidate for patients with pulmonary fibrosis.
- Journal
- Front Pharmacol
- Publish Year
- 2020
- Experiment Subject
- patient
- Experiment Type
- Cell Experiment
- Phenotype Related
- Idiopathic Pulmonary Fibrosis; Aging-associated Disease; Pulmonary Fibrosis
- Paper Title Cn
- Paper Title En
- Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence
- Bilingual Status
- semi_complete