ReferenceID 5213
Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
Nutrients
The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a stand
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Record Fields
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- Reference Id
- 5213
- Evidence Id
- 21803
- Core Evidence Id
- 21803
- Source Reference Id
- 3704
- Herb2 Reference Id
- HBREF004501
- Subject Paper Key
- HBIN026333_36364917
- Pubmed Id
- 36364917
- Doi
- 10.3390/nu14214656
- Paper Title
- Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
- Paper Abstract
- The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with d-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake d-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides , Prevotella , Clostridium, and Dysgonomonas while reducing Anaerofilum , Blautia, and Oribacterium in cecal content. In conclusion, d-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
- Bilingual Status
- semi_complete