ReferenceID 5198
Nephroprotective potential of eugenol in a rat experimental model of chronic kidney injury; targeting NOX, TGF-β, and Akt signaling
Life Sci
Chronic kidney disease is a crucial health problem associated with high morbidity and mortality. Eugenol is a natural phenolic plant compound with various pharmacological activities including antioxidant and anti-inflamm
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Record Fields
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- Reference Id
- 5198
- Evidence Id
- 21788
- Core Evidence Id
- 21788
- Source Reference Id
- 3684
- Herb2 Reference Id
- HBREF004481
- Subject Paper Key
- HBIN026067_36113730
- Pubmed Id
- 36113730
- Doi
- 10.1016/j.lfs.2022.120957
- Paper Title
- Nephroprotective potential of eugenol in a rat experimental model of chronic kidney injury; targeting NOX, TGF-β, and Akt signaling
- Paper Abstract
- Chronic kidney disease is a crucial health problem associated with high morbidity and mortality. Eugenol is a natural phenolic plant compound with various pharmacological activities including antioxidant and anti-inflammatory properties. This study was designed to evaluate the possible protective effect of different eugenol doses in an experimental model of chronic CCl 4 -induced renal damage and investigate various mechanisms that underlie this postulated effect. Eugenol treatment (100 mg/kg) ameliorated kidney damage induced by CCl 4 and rectified the distorted kidney function parameters and renal histological structure. Additionally, eugenol at a dose of 100 mg/kg suppressed the upregulated oxidative stress, inflammation and apoptosis in CCl 4 -treated rats as evident by down regulations of NADPH oxidase (NOX2 and NOX4), proinflammatory markers (IL-6 and TNF-α) and proapoptotic markers (cyt c and caspase-3), respectively. Importantly, eugenol co-administration in rats challenged with CCl 4 downregulated the renal protein expressions of both TGF-β as well as pAkt compared with CCl 4 group. In conclusion, eugenol showed a potent nephroprotective effect against CCl 4 -induced renal damage through its antioxidant, anti-inflammatory and anti-fibrotic activities.
- Journal
- Life Sci
- Publish Year
- 2022
- Experiment Subject
- rat; ccl 4
- Experiment Type
- Animal Experiment
- Phenotype Related
- Chronic Kidney Disease
- Paper Title Cn
- Paper Title En
- Nephroprotective potential of eugenol in a rat experimental model of chronic kidney injury; targeting NOX, TGF-β, and Akt signaling
- Bilingual Status
- semi_complete