ReferenceID 5164
Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
Cell Death Dis
Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of prostate cells and hyperproliferation of prostate tissue. This condition is closely related to chronic inflammation. In th
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5164
- Evidence Id
- 21754
- Core Evidence Id
- 21754
- Source Reference Id
- 3612
- Herb2 Reference Id
- HBREF004409
- Subject Paper Key
- HBIN025006_35715415
- Pubmed Id
- 35715415
- Doi
- 10.1038/s41419-022-04995-3
- Paper Title
- Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
- Paper Abstract
- Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of prostate cells and hyperproliferation of prostate tissue. This condition is closely related to chronic inflammation. In this study, we highlight the therapeutic efficacy of ellagic acid (EA) for BPH by focusing on the AR signaling axis and STAT3. To investigate the effect of EA on BPH, we used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate (TP)-induced BPH rats and RWPE-1 human prostate epithelial cells. The EA treatment reduced prostate weight, prostate epithelial thickness, and serum DHT levels in the TP-induced BPH rat model. In addition, EA improved testicular injury by increasing antioxidant enzymes in testis of the BPH rats. EA reduced the protein levels of AR, 5AR2, and PSA. It also induced apoptosis by regulating Bax, Bcl_xL, cytochrome c, caspase 9, and caspase 3 with increasing mitochondrial dynamics. Furthermore, EA reduced the expression of IL-6, TNF-α, and NF-κB, as well as phosphorylation of STAT3 and IκBα. These findings were also confirmed in TP-treated RWPE-1 cells. Overall, our data provide evidence of the role of EA in improving BPH through inhibition of AR and the STAT3 pathway.
- Journal
- Cell Death Dis
- Publish Year
- 2022
- Experiment Subject
- rat; human; men; tp-treated rwpe-1 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Hyperproliferation Of Prostate Tissue; Chronic Inflammation; Benign Prostate Hyperplasia; Age-related Disease
- Paper Title Cn
- Paper Title En
- Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
- Bilingual Status
- semi_complete