ReferenceID 5156
Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer
Food Funct
Ellagic acid (EA), a natural polyphenol compound that exists in a variety of fruits and vegetables, has been reported to inhibit tumor growth by reducing cell growth, inducing apoptosis, and damaging mitochondria. Recent
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Record Fields
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- Reference Id
- 5156
- Evidence Id
- 21746
- Core Evidence Id
- 21746
- Source Reference Id
- 3595
- Herb2 Reference Id
- HBREF004392
- Subject Paper Key
- HBIN025006_32608435
- Pubmed Id
- 32608435
- Doi
- 10.1039/d0fo01177k
- Paper Title
- Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer
- Paper Abstract
- Ellagic acid (EA), a natural polyphenol compound that exists in a variety of fruits and vegetables, has been reported to inhibit tumor growth by reducing cell growth, inducing apoptosis, and damaging mitochondria. Recent reports demonstrate that mitochondria regulate cancer cell death through energy metabolism and that different types of cell death coexist in vivo. We showed that EA inhibited lung cancer cell proliferation, markedly decreased ATP levels, decreased the potential of the inner mitochondrial membrane and decreased oxygen consumption in vitro. In addition, EA activated AMP-activated protein kinase (AMPK) and reduced HIF-1alpha in lung cancer cells. Moreover, the treatment of tumor-bearing mice with EA dramatically inhibited tumor growth, increased p-AMPK and suppressed HIF-1alpha levels. These findings suggest that EA could be a promising chemotherapeutic agent that targets mitochondrial metabolism in lung cancer.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Tumor; Cancer; Lung Cancer
- Paper Title Cn
- Paper Title En
- Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer
- Bilingual Status
- semi_complete