ReferenceID 5155
Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion
Int J Mol Sci
The immune system and the central nervous system message each other to preserving central homeostasis. Both systems undergo changes during aging that determine central age-related defects. Ellagic acid (EA) is a natural
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Record Fields
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- Reference Id
- 5155
- Evidence Id
- 21745
- Core Evidence Id
- 21745
- Source Reference Id
- 3594
- Herb2 Reference Id
- HBREF004391
- Subject Paper Key
- HBIN025006_32455600
- Pubmed Id
- 32455600
- Doi
- 10.3390/ijms21103631
- Paper Title
- Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion
- Paper Abstract
- The immune system and the central nervous system message each other to preserving central homeostasis. Both systems undergo changes during aging that determine central age-related defects. Ellagic acid (EA) is a natural product which is beneficial in both peripheral and central diseases, including aging. We analyzed the impact of the oral administration of a new oral ellagic acid micro-dispersion (EAm), that largely increased the EA solubility, in young and old mice. Oral EAm did not modify animal weight and behavioral skills in young and old mice, but significantly recovered changes in "ex-vivo, in vitro" parameters in old animals. Cortical noradrenaline exocytosis decreased in aged mice. EAm administration did not modify noradrenaline overflow in young animals, but recovered it in old mice. Furthermore, GFAP staining was increased in the cortex of aged mice, while IBA-1 and CD45 immunopositivities were unchanged when compared to young ones. EAm treatment significantly reduced CD45 signal in both young and old cortical lysates; it diminished GFAP immunopositivity in young mice, but failed to affect IBA-1 expression in both young and old animals. Finally, EAm treatment significantly reduced IL1beta expression in old mice. These results suggest that EAm is beneficial to aging and represents a nutraceutical ingredient for elders.
- Journal
- Int J Mol Sci
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Peripheral And Central Diseases
- Paper Title Cn
- Paper Title En
- Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion
- Bilingual Status
- semi_complete