ReferenceID 5143
Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
Int J Mol Sci
Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits. Glioblastoma multiforme (GBM) is the most malignant primary brain
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5143
- Evidence Id
- 21733
- Core Evidence Id
- 21733
- Source Reference Id
- 3567
- Herb2 Reference Id
- HBREF004364
- Subject Paper Key
- HBIN024193_34638796
- Pubmed Id
- 34638796
- Doi
- 10.3390/ijms221910453
- Paper Title
- Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
- Paper Abstract
- Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits. Glioblastoma multiforme (GBM) is the most malignant primary brain tumor; the average survival time of GBM patients is less than 18 months after standard treatment. The present study demonstrated that diosmin, which is able to cross the blood-brain barrier, inhibited GBM cell growth in vitro and in vivo. Diosmin also impeded migration and invasion by GBM8401and LN229 GBM cells by suppressing epithelial-mesenchymal transition, as indicated by increased expression of E-cadherin and decreased expression of Snail and Twist. Diosmin also suppressed autophagic flux, as indicated by increased expression of LC3-II and p62, and induced cell cycle arrest at G1 phase. Importantly, diosmin did not exert serious cytotoxic effects toward control SVG-p12 astrocytes, though it did reduce astrocyte viability at high concentrations. These findings provide potentially helpful support to the development of new therapies for the treatment of GBM.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- patient; gbm8401and ln229 gbm cells; svg-p12 astrocytes
- Experiment Type
- Cell Experiment
- Phenotype Related
- Glioblastoma Multiforme; Malignant Primary Brain Tumor
- Paper Title Cn
- Paper Title En
- Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
- Bilingual Status
- semi_complete