ReferenceID 5128
Dioscin Attenuates Myocardial Ischemic/Reperfusion-Induced Cardiac Dysfunction through Suppression of Reactive Oxygen Species
Oxid Med Cell Longev
Myocardial ischemic/reperfusion (MI/R) is a leading cause of cardiovascular disease with high morbidity and mortality. However, the mechanisms underlying pathological reperfusion remain obscure. In this study, we found t
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5128
- Evidence Id
- 21718
- Core Evidence Id
- 21718
- Source Reference Id
- 3538
- Herb2 Reference Id
- HBREF004335
- Subject Paper Key
- HBIN024134_34664015
- Pubmed Id
- 34664015
- Doi
- 10.1155/2021/3766919
- Paper Title
- Dioscin Attenuates Myocardial Ischemic/Reperfusion-Induced Cardiac Dysfunction through Suppression of Reactive Oxygen Species
- Paper Abstract
- Myocardial ischemic/reperfusion (MI/R) is a leading cause of cardiovascular disease with high morbidity and mortality. However, the mechanisms underlying pathological reperfusion remain obscure. In this study, we found that dioscin, a natural product, could be a potential candidate for treating MI/R through modulating cardiac dysfunction. Mechanistically, our work revealed that dioscin could suppress the production of reactive oxygen species (ROS) via repressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2) and enhancing the expression of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). These findings indicate that dioscin may be a potential candidate for therapeutic interventions in MI/R injury.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cardiovascular Disease; Cardiac Dysfunction; Mi/r Injury; Myocardial Ischemic/reperfusion
- Paper Title Cn
- Paper Title En
- Dioscin Attenuates Myocardial Ischemic/Reperfusion-Induced Cardiac Dysfunction through Suppression of Reactive Oxygen Species
- Bilingual Status
- semi_complete