ReferenceID 5125
Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway
Food Chem Toxicol
The present study emphasized on the anti-cancerous effects of dioscin and its underlying molecular mechanism in human endometrial cancer Ishikawa cells. Dioscin significantly suppressed the proliferation of Ishikawa cell
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Record Fields
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- Reference Id
- 5125
- Evidence Id
- 21715
- Core Evidence Id
- 21715
- Source Reference Id
- 3533
- Herb2 Reference Id
- HBREF004330
- Subject Paper Key
- HBIN024134_33359023
- Pubmed Id
- 33359023
- Doi
- 10.1016/j.fct.2020.111941
- Paper Title
- Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway
- Paper Abstract
- The present study emphasized on the anti-cancerous effects of dioscin and its underlying molecular mechanism in human endometrial cancer Ishikawa cells. Dioscin significantly suppressed the proliferation of Ishikawa cells at IC50 of 2.37 muM. Besides, dioscin could inhibit the proliferation of Ishikawa cells by blocking the G0/G1 cell cycle through up-regulation of p16, p21, and p27 and down-regulation of cycle-cellular protein (Cyclin A/D/E) and cyclin-dependent kinase (CDK2/4/6). Also, it promoted apoptosis through the mitochondrial pathway, including the regulation of Bcl family proteins, the increase of ROS levels, the activation of caspases (Caspase 9/3), and the decrease of mitochondrial membrane permeability. Whereas dioscin also effectively activated the marker genes and proteins (Fas, TNF-R1, and Caspase 8) related to the death receptor-mediated pathway which confirmed the involvement of both the pathways for dioscin-induced apoptosis. The current results demonstrated that dioscin possessed potential health benefits with respect to endometrial cancer prevention and treatment.
- Journal
- Food Chem Toxicol
- Publish Year
- 2021
- Experiment Subject
- human; human endometrial cancer ishikawa cells; ishikawa cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Endometrial Cancer
- Paper Title Cn
- Paper Title En
- Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway
- Bilingual Status
- semi_complete