ReferenceID 5120
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression
J Lipid Res
Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated
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Record Fields
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- Reference Id
- 5120
- Evidence Id
- 21710
- Core Evidence Id
- 21710
- Source Reference Id
- 5054
- Herb2 Reference Id
- HBREF005851
- Subject Paper Key
- HBIN038043_36030930
- Pubmed Id
- 36030930
- Doi
- 10.1016/j.jlr.2022.100268
- Paper Title
- Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression
- Paper Abstract
- Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood. However, in a previous study, we observed that chronically increased RBP4 by forced Rbp4 expression in the liver does not impair glucose homeostasis in mice. Here, we investigated the effects of an acute mobilization of hepatic vitamin A stores by hepatic overexpression of RBP4 in mice. We show that hepatic retinol mobilization decreases body fat content and enhances fat turnover. Mechanistically, we found that acute retinol mobilization increases hepatic expression and serum levels of fibroblast growth factor 21 (FGF21), which is regulated by retinol mobilization and retinoic acid in primary hepatocytes. Moreover, we provide evidence that the insulin-sensitizing effect of FGF21 is associated with organ-specific adaptations in retinoid homeostasis. Taken together, our findings identify a novel crosstalk between retinoid homeostasis and FGF21 in mice with acute RBP4-mediated retinol mobilization from the liver.
- Journal
- J Lipid Res
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Obesity
- Paper Title Cn
- Paper Title En
- Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression
- Bilingual Status
- semi_complete