ReferenceID 5113
Dieckol, an algae-derived phenolic compound, suppresses airborne particulate matter-induced skin aging by inhibiting the expressions of pro-inflammatory cytokines and matrix metalloproteinases through regulating NF-κB, AP-1, and MAPKs signaling pathways
Food Chem Toxicol
Exposure to particulate matter causes skin aging. In the present study, we investigated the effect of an algae-derived phenolic compound, dieckol (DK), against Chinese particulate matter (CPM)-stimulated aging in vitro i
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5113
- Evidence Id
- 21703
- Core Evidence Id
- 21703
- Source Reference Id
- 3513
- Herb2 Reference Id
- HBREF004310
- Subject Paper Key
- HBIN023738_33164846
- Pubmed Id
- 33164846
- Doi
- 10.1016/j.fct.2020.111823
- Paper Title
- Dieckol, an algae-derived phenolic compound, suppresses airborne particulate matter-induced skin aging by inhibiting the expressions of pro-inflammatory cytokines and matrix metalloproteinases through regulating NF-κB, AP-1, and MAPKs signaling pathways
- Paper Abstract
- Exposure to particulate matter causes skin aging. In the present study, we investigated the effect of an algae-derived phenolic compound, dieckol (DK), against Chinese particulate matter (CPM)-stimulated aging in vitro in human dermal fibroblasts (HDF cells) and in vivo in zebrafish. DK effectively protected HDF cells against CPM-induced oxidative stress by scavenging intracellular reactive oxygen species. Moreover, DK significantly improved collagen synthesis and inhibited intracellular collagenase activity in CPM-stimulated HDF cells. In addition, DK remarkably reduced the expression of pro-inflammatory cytokines and matrix metalloproteinases via regulating the nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases signaling pathways in CPM-stimulated HDF cells. Furthermore, the in vivo test results demonstrated that DK effectively improved the survival rate of CPM-stimulated zebrafish via suppressing oxidative stress and inflammatory response. In conclusion, this study suggests that DK is a potential anti-aging compound that can be used as a therapeutic agent to improve CPM-induced skin aging, or as an ingredient to develop a cosmetic or medicine in the cosmeceutical and pharmaceutical industries.
- Journal
- Food Chem Toxicol
- Publish Year
- 2020
- Experiment Subject
- human; cpm-stimulated hdf cells; hdf cells; zebrafish
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Dieckol, an algae-derived phenolic compound, suppresses airborne particulate matter-induced skin aging by inhibiting the expressions of pro-inflammatory cytokines and matrix metalloproteinases through regulating NF-κB, AP-1, and MAPKs signaling pathways
- Bilingual Status
- semi_complete