ReferenceID 5094
Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro
Int Immunopharmacol
The inflammatory radicular pain induced by lumbar disc herniation (LDH) is a serious problem worldwide. Demethoxycurcumin (DMC) is a yellow pigment derived from turmeric. Although it is considered a safe natural compound
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Record Fields
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- Reference Id
- 5094
- Evidence Id
- 21684
- Core Evidence Id
- 21684
- Source Reference Id
- 3478
- Herb2 Reference Id
- HBREF004275
- Subject Paper Key
- HBIN023227_35729841
- Pubmed Id
- 35729841
- Doi
- 10.1016/j.intimp.2022.108914
- Paper Title
- Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro
- Paper Abstract
- The inflammatory radicular pain induced by lumbar disc herniation (LDH) is a serious problem worldwide. Demethoxycurcumin (DMC) is a yellow pigment derived from turmeric. Although it is considered a safe natural compound for managing inflammation-associated diseases, but the molecular mechanisms of LDH remain to be elucidated. In the current study, DMC reduced the production of IL-1β, IL-4, and IL-6 in nucleus pulposus (NP) cells subjected to TNF-α-induced inflammation. Moreover, the inhibitory mechanism was activated upon suppression of activation of MAPKs and NF-κB signalling in NP cells. Further experiments with LDH model rats supported the in vitro results. These studies expand our knowledge of the effect of DMC on LDH; DMC may be a viable alternative to the drugs used to treat LDH.
- Journal
- Int Immunopharmacol
- Publish Year
- 2022
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Lumbar Disc Herniation; Inflammation-associated Diseases; Inflammatory Radicular Pain
- Paper Title Cn
- Paper Title En
- Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro
- Bilingual Status
- semi_complete