ReferenceID 5084
Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
Front Pharmacol
Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the deve
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Record Fields
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- Reference Id
- 5084
- Evidence Id
- 21674
- Core Evidence Id
- 21674
- Source Reference Id
- 3452
- Herb2 Reference Id
- HBREF004249
- Subject Paper Key
- HBIN022781_34925018
- Pubmed Id
- 34925018
- Doi
- 10.3389/fphar.2021.758962
- Paper Title
- Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
- Paper Abstract
- Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is a vital part of endothelial dysfunction. Dauricine is an extract isolated from Menispermum dauricum DC, a traditional Chinese medical plant that can be used for pharyngitis. In this work, we found that IL-1beta-induced overexpression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin was inhibited by dauricine in primary human umbilical vein endothelial cells (HUVECs). Correspondingly, adhesion of human acute monocytic leukemia cell line (THP-1) to HUVECs was decreased by dauricine. Further studies showed that dauricine inhibited the activation of nuclear factor-kappaB (NF-kappaB) pathway in HUVECs stimulated with IL-1beta. In vivo, dauricine protected mice from lipopolysaccharide (LPS)-induced acute lung injury. In lung tissues, the activation of NF-kappaB pathway and the expression of its downstream genes (ICAM-1, VCAM-1, and E-selectin) were decreased by dauricine, consistent with what was found in vitro. In summary, we concluded that dauricine could alleviate endothelial inflammation by suppressing NF-kappaB pathway, which might serve as an effective candidate for diseases related with endothelial inflammation.
- Journal
- Front Pharmacol
- Publish Year
- 2021
- Experiment Subject
- mouse; human; human acute monocytic leukemia cell line; huvecs; primary human umbilical vein endothelial cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Acute Monocytic Leukemia; Endothelial Inflammation; Endothelial Dysfunction; Acute Lung Injury; Pharyngitis
- Paper Title Cn
- Paper Title En
- Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
- Bilingual Status
- semi_complete