ReferenceID 503
Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation
Pharmacol Res
In the present study we chemically profiled tannin-enriched extracts from strawberries and tested their biological properties in a cell model of gastric inflammation. The chemical and biological features of strawberry ta
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Record Fields
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- Reference Id
- 503
- Evidence Id
- 17093
- Core Evidence Id
- 17093
- Source Reference Id
- 979
- Herb2 Reference Id
- HBREF001690
- Subject Paper Key
- HBIN014896_27473819
- Pubmed Id
- 27473819
- Doi
- 10.1016/j.phrs.2016.07.028
- Paper Title
- Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation
- Paper Abstract
- In the present study we chemically profiled tannin-enriched extracts from strawberries and tested their biological properties in a cell model of gastric inflammation. The chemical and biological features of strawberry tannins after in vitro simulated gastric digestion were investigated as well. The anti-inflammatory activities of pure strawberry tannins were assayed to get mechanistic insights. Tannin-enriched extracts from strawberries inhibit IL-8 secretion in TNFα-treated human gastric epithelial cells by dampening the NF-κB signaling. In vitro simulated gastric digestion slightly affected the chemical composition and the biological properties of strawberry tannins. By using pure compounds, we found that casuarictin may act as a pure NF-κB inhibitor while agrimoniin inhibits IL-8 secretion also acting on other biological targets; in our system procyanidin B1 prevents the TNFα-induced effects without interfering with the NF-κB pathway. We conclude that strawberry tannins, even after in vitro simulated gastric digestion, exert anti-inflammatory activities at nutritionally relevant concentrations.
- Journal
- Pharmacol Res
- Publish Year
- 2016
- Experiment Subject
- cell model of gastric inflammation
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation
- Bilingual Status
- semi_complete