ReferenceID 4969
Biological Evaluation and Transcriptomic Analysis of Corylin as an Inhibitor of Osteoclast Differentiation
Int J Mol Sci
Corylin, a flavonoid isolated from the fruit of Psoralea corylifolia, has an osteogenic effect on osteoblasts in vitro and bone micromass ex vivo. However, the effect and mechanism of corylin in regulating osteoclastogen
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Record Fields
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- Reference Id
- 4969
- Evidence Id
- 21559
- Core Evidence Id
- 21559
- Source Reference Id
- 3185
- Herb2 Reference Id
- HBREF003982
- Subject Paper Key
- HBIN021561_33805517
- Pubmed Id
- 33805517
- Doi
- 10.3390/ijms22073540
- Paper Title
- Biological Evaluation and Transcriptomic Analysis of Corylin as an Inhibitor of Osteoclast Differentiation
- Paper Abstract
- Corylin, a flavonoid isolated from the fruit of Psoralea corylifolia, has an osteogenic effect on osteoblasts in vitro and bone micromass ex vivo. However, the effect and mechanism of corylin in regulating osteoclastogenesis remain unknown. By using murine bone marrow macrophages as the osteoclast precursor, corylin was found to inhibit the receptor activator of nuclear factor (NF) kappaB ligand (RANKL)-induced osteoclast differentiation via down-regulating osteoclastic marker genes. In parallel, F-actin formation and osteoclast migration were diminished in corylin-treated cultured osteoclasts, and subsequently the expressions of osteoclastic proteins were suppressed: the suppression of protein expression was further illustrated by transcriptomic analysis. Furthermore, corylin inhibited the nuclear translocation of p65, giving rise to a restraint in osteoclastic differentiation through the attenuation of transcription factors nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and nuclear factor of activated T cells c1 (NFATc1). There was no obvious change in apoptosis when the RANKL-induce osteoclasts were cultured in the presence of corylin. The finding supports the potential development of corylin as an osteoclast inhibitor against osteoporosis.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- mouse; corylin-treated cultured osteoclasts
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Osteoporosis
- Paper Title Cn
- Paper Title En
- Biological Evaluation and Transcriptomic Analysis of Corylin as an Inhibitor of Osteoclast Differentiation
- Bilingual Status
- semi_complete