ReferenceID 4944
Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction
Eur J Pharmacol
Purpose: Several studies have reported that colchicine attenuates cardiac inflammation and improves cardiac function in myocardial infarction and atrial fibrillation. However, no study has investigated its effect on hear
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- Reference Id
- 4944
- Evidence Id
- 21534
- Core Evidence Id
- 21534
- Source Reference Id
- 3143
- Herb2 Reference Id
- HBREF003940
- Subject Paper Key
- HBIN021260_35779623
- Pubmed Id
- 35779623
- Doi
- 10.1016/j.ejphar.2022.175126
- Paper Title
- Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction
- Paper Abstract
- Purpose: Several studies have reported that colchicine attenuates cardiac inflammation and improves cardiac function in myocardial infarction and atrial fibrillation. However, no study has investigated its effect on heart failure with preserved ejection fraction (HFpEF). Hence, this study aimed to assess its efficacy in a high salt diet (HSD)-induced HFpEF rat model. Methods: A rat hypertension-induced HFpEF model was created by treating Dahl/SS salt-sensitive rats with an HSD for 6 weeks. Colchicine was given via gavage daily as treatment. Cardiac function and inflammation were assessed using echocardiography, histology, and ELISA. Furthermore, the expression levels of NLRP3 and NF-κB signaling pathways were examined. Results: Treatment with colchicine increased survival and attenuated cardiac dysfunction, as indicated by decreased echocardiographic E/A ratio and longer exercise endurance along with reduced ventricular fibrosis and remodeling in HSD-induced Dahl rats. The treatment also reduced cardiac oxidative stress and inflammatory cell infiltration, as inferred from lower mRNA expressions of TNFα and CCL2 as well as protein expressions of NLRP3 and NF-κB pathways. Conclusion: The findings signify that colchicine plays a crucial role in alleviating systemic inflammation and NLRP3 inflammation activation as well as in attenuating cardiac dysfunction and fibrosis in HSD-induced HFpEF model. Colchicine, therefore, holds therapeutic potential for further clinical applications.
- Journal
- Eur J Pharmacol
- Publish Year
- 2022
- Experiment Subject
- rat; hfpef model
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cardiac Inflammation; Hfpef; Atrial Fibrillation; Systemic Inflammation; Cardiac Dysfunction; Heart Failure; Fibrosis; Myocardial Infarction; Ventricular Fibrosis; Preserved Ejection Fraction
- Paper Title Cn
- Paper Title En
- Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction
- Bilingual Status
- semi_complete