ReferenceID 4895
Protective effects of chicoric acid on LPS-induced endometritis in mice via inhibiting ferroptosis by Nrf2/HO-1 signal axis
Int Immunopharmacol
Chicoric acid (CA), a natural phenolic acid extracted from Mediterranean vegetable chicory, has anti-oxidative effect. We aimed to investigate the effects of CA on endometritis and clarify the underlying mechanism. C57BL
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Record Fields
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- Reference Id
- 4895
- Evidence Id
- 21485
- Core Evidence Id
- 21485
- Source Reference Id
- 3036
- Herb2 Reference Id
- HBREF003833
- Subject Paper Key
- HBIN020288_36403522
- Pubmed Id
- 36403522
- Doi
- 10.1016/j.intimp.2022.109435
- Paper Title
- Protective effects of chicoric acid on LPS-induced endometritis in mice via inhibiting ferroptosis by Nrf2/HO-1 signal axis
- Paper Abstract
- Chicoric acid (CA), a natural phenolic acid extracted from Mediterranean vegetable chicory, has anti-oxidative effect. We aimed to investigate the effects of CA on endometritis and clarify the underlying mechanism. C57BL/6 mice were divided into five groups: control group, LPS group, and LPS + CA groups. All mice except control group were infused of LPS into the uterus. The mice of LPS + CA groups were intraperitoneally injected CA 1 h before LPS challenge. CA significantly alleviatedLPS-induced pathological damage, MPO activity, and inflammatory cytokine production. CA significantly suppressed ferroptosis in LPS-induced endometritis. CA also attenuated LPS-induced NF-κB activation. Furthermore, Nrf2 and HO-1 expression were increased by CA. Moreover, the inhibition of CA on LPS-induced endometritis and ferroptosis were markedly prevented in Nrf2 knockdown mice. In conclusion, the results suggested CA protected mice against LPS-induced endometritisthrough inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.
- Journal
- Int Immunopharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Ferroptosis; Endometritis
- Paper Title Cn
- Paper Title En
- Protective effects of chicoric acid on LPS-induced endometritis in mice via inhibiting ferroptosis by Nrf2/HO-1 signal axis
- Bilingual Status
- semi_complete