ReferenceID 4849
Capsaicin Inhibits Shigella flexneri Intracellular Growth by Inducing Autophagy
Front Pharmacol
Antibiotic treatment plays an essential role in preventing Shigella infection. However, incidences of global rise in antibiotic resistance create a major challenge to treat bacterial infection. In this context, there is
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4849
- Evidence Id
- 21439
- Core Evidence Id
- 21439
- Source Reference Id
- 2948
- Herb2 Reference Id
- HBREF003745
- Subject Paper Key
- HBIN019690_35873583
- Pubmed Id
- 35873583
- Doi
- 10.3389/fphar.2022.903438
- Paper Title
- Capsaicin Inhibits Shigella flexneri Intracellular Growth by Inducing Autophagy
- Paper Abstract
- Antibiotic treatment plays an essential role in preventing Shigella infection. However, incidences of global rise in antibiotic resistance create a major challenge to treat bacterial infection. In this context, there is an urgent need for newer approaches to reduce S. flexneri burden. This study largely focuses on the role of the herbal compound capsaicin (Caps) in inhibiting S. flexneri growth and evaluating the molecular mechanism behind bacterial clearance. Here, we show for the first time that Caps inhibits intracellular S. flexneri growth by inducing autophagy. Activation of autophagy by Caps is mediated through transcription factor TFEB, a master regulator of autophagosome biogenesis. Caps induced the nuclear localization of TFEB. Activation of TFEB further induces the gene transcription of autophagosomal genes. Our findings revealed that the inhibition of autophagy by silencing TFEB and Atg5 induces bacterial growth. Hence, Caps-induced autophagy is one of the key factors responsible for bacterial clearance. Moreover, Caps restricted the intracellular proliferation of S. flexneri -resistant strain. The efficacy of Caps in reducing S. flexneri growth was confirmed by an animal model. This study showed for the first time that S. flexneri infection can be inhibited by inducing autophagy. Overall observations suggest that Caps activates TFEB to induce autophagy and thereby combat S. flexneri infection.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Bacterial Infection; Shigella Infection
- Paper Title Cn
- Paper Title En
- Capsaicin Inhibits Shigella flexneri Intracellular Growth by Inducing Autophagy
- Bilingual Status
- semi_complete