ReferenceID 4800
Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF- κ B/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
Front Oncol
The neddylation pathway is overactivated in esophageal cancer. Our previous studies indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and autophagy in cancer cells. Camptothecin (CPT), a w
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4800
- Evidence Id
- 21390
- Core Evidence Id
- 21390
- Source Reference Id
- 2853
- Herb2 Reference Id
- HBREF003650
- Subject Paper Key
- HBIN019519_33898327
- Pubmed Id
- 33898327
- Doi
- 10.3389/fonc.2021.671180
- Paper Title
- Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF- κ B/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
- Paper Abstract
- The neddylation pathway is overactivated in esophageal cancer. Our previous studies indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and autophagy in cancer cells. Camptothecin (CPT), a well-known anticancer agent, could induce apoptosis and autophagy in cancer cells. However, whether CPT could affect the neddylation pathway and the molecular mechanisms of CPT-induced autophagy in esophageal cancer remains elusive. We found that CPT induced apoptosis and autophagy in esophageal cancer. Mechanistically, CPT inhibited the activity of neddylation and induced the accumulation of p-IkBa to block NF-kappaB pathway. Furthermore, CPT induced the generation of ROS to modulate the AMPK/mTOR/ULK1 axis to finally promote protective autophagy. In our study, we elucidate a novel mechanism of the NF-kappaB/AMPK/mTOR/ULK1 pathway in CPT-induced protective autophagy in esophageal cancer cells, which provides a sound rationale for combinational anti-ESCC therapy with CPT and inhibition AMPK/ULK1 pathway.
- Journal
- Front Oncol
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Esophageal Cancer; Cancer
- Paper Title Cn
- Paper Title En
- Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF- κ B/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
- Bilingual Status
- semi_complete