ReferenceID 4753
Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
Front Oncol
Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits t
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Record Fields
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- Reference Id
- 4753
- Evidence Id
- 21343
- Core Evidence Id
- 21343
- Source Reference Id
- 2742
- Herb2 Reference Id
- HBREF003539
- Subject Paper Key
- HBIN018727_34917504
- Pubmed Id
- 34917504
- Doi
- 10.3389/fonc.2021.749987
- Paper Title
- Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- Paper Abstract
- Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the potential radiosensitizing effects of borneol and the underlying mechanisms. We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo. Furthermore, borneol markedly increased the number of autophagosomes in the glioma cells, which coincided with increased expression of beclin-1 and LC3. And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1alpha, mTORC1 and eIF4E. In addition, silencing mTORC1 and eIF4E upregulated Beclin-1 and LC3 and decreased the expression of HIF-1alpha, thereby inhibiting tumor cell proliferation. Our findings suggest that borneol sensitizes glioma cells to radiation by inducing autophagy via inhibition of the mTORC1/eIF4E/HIF-1alpha regulatory axis.
- Journal
- Front Oncol
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Craniocerebral Malignancy; Tumor; Glioma
- Paper Title Cn
- Paper Title En
- Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- Bilingual Status
- semi_complete