ReferenceID 4746
Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
Oxid Med Cell Longev
Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherog
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- Reference Id
- 4746
- Evidence Id
- 21336
- Core Evidence Id
- 21336
- Source Reference Id
- 2731
- Herb2 Reference Id
- HBREF003528
- Subject Paper Key
- HBIN018523_33959213
- Pubmed Id
- 33959213
- Doi
- 10.1155/2020/8965047
- Paper Title
- Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
- Paper Abstract
- Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherogenesis. The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms. Our results showed that administration of BCA promoted reverse cholesterol transport (RCT), improved plasma lipid profile, and decreased serum proinflammatory cytokine levels and atherosclerotic lesion area in apoE-/- mice fed a Western diet. In THP-1 macrophage-derived foam cells, treatment with BCA upregulated ATP-binding cassette (ABC) transporter A1 (ABCA1) and ABCG1 expression and facilitated subsequent cholesterol efflux and diminished intracellular cholesterol contents by activating the peroxisome proliferator-activated receptor gamma (PPARgamma)/liver X receptor alpha (LXRalpha) and PPARgamma/heme oxygenase 1 (HO-1) pathways. BCA also activated these two signaling pathways to inhibit the secretion of proinflammatory cytokines. Taken together, these findings suggest that BCA is protective against atherosclerosis by inhibiting lipid accumulation and inflammatory response through the PPARgamma/LXRalpha and PPARgamma/HO-1 pathways. BCA may be an attractive drug for the prevention and treatment of atherosclerotic cardiovascular disease.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2020
- Experiment Subject
- mouse; cabbage; thp-1 macrophage-derived foam cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Myocardial Ischemia/reperfusion Injury; Atherosclerotic Cardiovascular Disease; Atherosclerotic Lesion; Atherosclerosis; Hypertension
- Paper Title Cn
- Paper Title En
- Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
- Bilingual Status
- semi_complete