ReferenceID 4743
Bilobalide inhibits inflammation and promotes the expression of Aβ degrading enzymes in astrocytes to rescue neuronal deficiency in AD models
Transl Psychiatry
The pathogenesis of Alzheimer's disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in single cell type may not be sufficient to treat
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4743
- Evidence Id
- 21333
- Core Evidence Id
- 21333
- Source Reference Id
- 2725
- Herb2 Reference Id
- HBREF003522
- Subject Paper Key
- HBIN018512_34671017
- Pubmed Id
- 34671017
- Doi
- 10.1038/s41398-021-01594-2
- Paper Title
- Bilobalide inhibits inflammation and promotes the expression of Aβ degrading enzymes in astrocytes to rescue neuronal deficiency in AD models
- Paper Abstract
- The pathogenesis of Alzheimer's disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in single cell type may not be sufficient to treat AD and therapies with protective effects in multiple cell types may be more effective. Here, we comprehensively investigated the effects of bilobalide on neuroinflammation and Abeta degrading enzymes in AD cell model and mouse model. We find that bilobalide inhibits Abeta-induced and STAT3-dependent expression of TNF-alpha, IL-1beta, and IL-6 in primary astrocyte culture. Bilobalide also induces robust expression of Abeta degrading enzymes like NEP, IDE, and MMP2 to facilitate astrocyte-mediated Abeta clearance. Moreover, bilobalide treatment of astrocyte rescues neuronal deficiency in co-cultured APP/PS1 neurons. Most importantly, bilobalide reduces amyloid and inflammation in AD mouse brain. Taken together, the protective effects of bilobalide in in vitro cultures were fully recapitulated in in vivo AD mouse model. Our study supports that bilobalide has therapeutic potential for AD treatment.
- Journal
- Transl Psychiatry
- Publish Year
- 2021
- Experiment Subject
- mouse; co-cultured app/ps1 neurons; in vitro cultures
- Experiment Type
- Animal Experiment
- Phenotype Related
- Neuronal Deficiency; Alzheimer's Disease
- Paper Title Cn
- Paper Title En
- Bilobalide inhibits inflammation and promotes the expression of Aβ degrading enzymes in astrocytes to rescue neuronal deficiency in AD models
- Bilingual Status
- semi_complete