ReferenceID 4733
Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice
Int J Mol Sci
Acute pancreatitis (AP) is an inflammatory disorder, involving acinar cell death and the release of inflammatory cytokines. Currently, there are limited effective therapeutic agents for AP. Betulinic acid (BA) is a penta
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Record Fields
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- Reference Id
- 4733
- Evidence Id
- 21323
- Core Evidence Id
- 21323
- Source Reference Id
- 2710
- Herb2 Reference Id
- HBREF003507
- Subject Paper Key
- HBIN018373_34206763
- Pubmed Id
- 34206763
- Doi
- 10.3390/ijms22136871
- Paper Title
- Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice
- Paper Abstract
- Acute pancreatitis (AP) is an inflammatory disorder, involving acinar cell death and the release of inflammatory cytokines. Currently, there are limited effective therapeutic agents for AP. Betulinic acid (BA) is a pentacyclic triterpenoid extracted from Betula platyphylla that has been shown to have anti-inflammatory effects. In this study, we aimed to investigate the effects of BA on AP and elucidate the potential underlying mechanisms. AP was induced in mice through six intraperitoneal injections of cerulein. After the last cerulein injection, the mice were sacrificed. Our results revealed that pre- and post-treatment with BA significantly reduced the severity of pancreatitis, as evidenced by a decrease in histological damage in the pancreas and lung, serum amylase and lipase activity and pancreatic myeloperoxidase activity. Furthermore, BA pretreatment reduced proinflammatory cytokine production, augmentation of chemokines, and infiltration of macrophages and neutrophils in the pancreas of AP mice. In addition, mice that were pretreated with BA showed a reduction in Ikappa-Balpha degradation and nuclear factor-kappa B (NF-kappaB) binding activity in the pancreas. Moreover, BA reduced the production of proinflammatory cytokines and NF-kappaB activation in pancreatic acinar cells (PACs). These findings suggest that BA may have prophylactic and therapeutic effects on AP via inhibition of the NF-kappaB signaling pathway.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Acute Pancreatitis; Pancreatitis; Inflammatory Disorder; Acinar Cell Death
- Paper Title Cn
- Paper Title En
- Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice
- Bilingual Status
- semi_complete