ReferenceID 4729
β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade
J Cell Physiol
beta-Mangostin is a natural mangostin with potent anticancer activity against various cancers. In this study, we further explored the anticancer activity of beta-mangostin on cervical cancer cells. beta-Mangostin did not
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Record Fields
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- Reference Id
- 4729
- Evidence Id
- 21319
- Core Evidence Id
- 21319
- Source Reference Id
- 2705
- Herb2 Reference Id
- HBREF003502
- Subject Paper Key
- HBIN018187_32324277
- Pubmed Id
- 32324277
- Doi
- 10.1002/jcp.29688
- Paper Title
- β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade
- Paper Abstract
- beta-Mangostin is a natural mangostin with potent anticancer activity against various cancers. In this study, we further explored the anticancer activity of beta-mangostin on cervical cancer cells. beta-Mangostin did not affect cell viability and cell cycle distribution in HeLa and SiHa cells; however, it dose-dependently inhibited the migration and invasion of both the human cervical cancer cell lines. In addition, we observed that beta-mangostin suppressed the expression of integrin alphaV and beta3 and the downstream focal adhesion kinase/Src signaling. We also found that Snail was involved in the beta-mangostin inhibited cell migration and invasion of HeLa cell. Then, our findings showed that beta-mangostin reduced both nuclear translocation and messenger RNA expression of AP-1 and demonstrated that AP-1 could target to the Snail promoter and induce Snail expression. Kinase cascade analysis and reporter assay showed that JNK2 was involved in the inhibition of AP-1/Snail axis by beta-mangostin in HeLa cells. These results indicate that beta-mangostin can inhibit the mobility and invasiveness of cervical cancer cells, which may attribute to the suppression of both integrin/Src signaling and JNK2-mediated AP-1/Snail axis. This suggests that beta-mangostin has potential antimetastatic potential against cervical cancer cells.
- Journal
- J Cell Physiol
- Publish Year
- 2020
- Experiment Subject
- human; hela; hela cell; hela cells; human cervical cancer cell lines; siha cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cancers; Cervical Cancer
- Paper Title Cn
- Paper Title En
- β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade
- Bilingual Status
- semi_complete