ReferenceID 4728
β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice
Nutrients
We investigated the effects of beta-cryptoxanthin on skeletal muscle atrophy in senescence-accelerated mouse-prone 1 (SAMP1) mice. For 15 weeks, SAMP1 mice were intragastrically administered vehicle or beta-cryptoxanthin
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Record Fields
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- Reference Id
- 4728
- Evidence Id
- 21318
- Core Evidence Id
- 21318
- Source Reference Id
- 2704
- Herb2 Reference Id
- HBREF003501
- Subject Paper Key
- HBIN018032_32708051
- Pubmed Id
- 32708051
- Doi
- 10.3390/nu12082180
- Paper Title
- β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice
- Paper Abstract
- We investigated the effects of beta-cryptoxanthin on skeletal muscle atrophy in senescence-accelerated mouse-prone 1 (SAMP1) mice. For 15 weeks, SAMP1 mice were intragastrically administered vehicle or beta-cryptoxanthin. At 35 weeks of age, the skeletal muscle mass in SAMP1 mice was reduced compared with that in control senescence-accelerated mouse-resistant 1 (SAMR1) mice. beta-cryptoxanthin increased muscle mass with an increase in the size of muscle fibers in the soleus muscle of SAMP1 mice. The expressions of autophagy-related factors such as beclin-1, p62, LC3-I, and LC3-II were increased in the soleus muscle of SAMP1 mice; however, beta-cryptoxanthin administration inhibited this increase. Unlike in SAMR1 mice, p62 was punctately distributed throughout the cytosol in the soleus muscle fibers of SAMP1 mice; however, beta-cryptoxanthin inhibited this punctate distribution. The cross-sectional area of p62-positive fiber was smaller than that of p62-negative fiber, and the ratio of p62-positive fibers to p62-negative fibers was increased in SAMP1 mice. beta-cryptoxanthin decreased this ratio in SAMP1 mice. Furthermore, beta-cryptoxanthin decreased the autophagy-related factor expression in murine C2C12 myotube. The autophagy inhibitor bafilomycin A1, but not the proteasome inhibitor MG132, inhibited the beta-cryptoxanthin-induced decrease in p62 and LC3-II expressions. These results indicate that beta-cryptoxanthin inhibits the p62 accumulation in fibers and improves muscle atrophy in the soleus muscle of SAMP1 mice.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- mouse; murine c2c12 myotube
- Experiment Type
- Animal Experiment
- Phenotype Related
- Muscle Atrophy
- Paper Title Cn
- Paper Title En
- β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice
- Bilingual Status
- semi_complete