ReferenceID 469
Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
FASEB J
Energy expenditure is a target gaining recent interest for obesity treatment. The antiobesity effect of vanillic acid (VA), a well-known flavoring agent, was investigated in vivo and in vitro. High-fat diet (HFD)-induced
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Record Fields
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- Reference Id
- 469
- Evidence Id
- 17059
- Core Evidence Id
- 17059
- Source Reference Id
- 914
- Herb2 Reference Id
- HBREF001569
- Subject Paper Key
- HBIN047738_29141998
- Pubmed Id
- 29141998
- Doi
- 10.1096/fj.201700231RR
- Paper Title
- Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
- Paper Abstract
- Energy expenditure is a target gaining recent interest for obesity treatment. The antiobesity effect of vanillic acid (VA), a well-known flavoring agent, was investigated in vivo and in vitro. High-fat diet (HFD)-induced obese mice and genetically obese db/db mice showed significantly decreased body weights after VA administration. Two major adipogenic markers, peroxisome proliferator activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), were reduced while the key factor of energy metabolism, AMPKα, was increased in the white adipose tissue and liver tissue of VA-treated mice. Furthermore, VA inhibited lipid accumulation and reduced hepatotoxic/inflammatory markers in liver tissues of mice and HepG2 hepatocytes. VA treatment also decreased differentiation of 3T3-L1 adipocytes by regulating adipogenic factors including PPARγ and C/EBPα. AMPKα small interfering RNA was used to examine whether AMPK was associated with the actions of VA. In AMPKα-nulled 3T3-L1 cells, the inhibitory action of VA on PPARγ and C/EBPα was attenuated. Furthermore, in brown adipose tissues of mice and primary cultured brown adipocytes, VA increased mitochondria- and thermogenesis-related factors such as uncoupling protein 1 and PPARγ-coactivator 1-α. Taken together, our results suggest that VA has potential as an AMPKα- and thermogenesis-activating antiobesity agent.-Jung, Y., Park, J., Kim, H.-L., Sim, J.-E., Youn, D.-H., Kang, J., Lim, S., Jeong, M.-Y., Yang, W. M., Lee, S.-G., Ahn, K. S., Um, J.-Y. Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro.
- Journal
- FASEB J
- Publish Year
- 2018
- Experiment Subject
- obese db/db mice
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
- Bilingual Status
- semi_complete