ReferenceID 4632
Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway
Clin Exp Immunol
Lipid accumulation and inflammatory response are two major risk factors for atherosclerosis. Baicalein, a phenolic flavonoid widely used in East Asian countries, possesses a potential atheroprotective activity. However,
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Record Fields
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- Reference Id
- 4632
- Evidence Id
- 21222
- Core Evidence Id
- 21222
- Source Reference Id
- 2531
- Herb2 Reference Id
- HBREF003328
- Subject Paper Key
- HBIN017508_35749304
- Pubmed Id
- 35749304
- Doi
- 10.1093/cei/uxac062
- Paper Title
- Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway
- Paper Abstract
- Lipid accumulation and inflammatory response are two major risk factors for atherosclerosis. Baicalein, a phenolic flavonoid widely used in East Asian countries, possesses a potential atheroprotective activity. However, the underlying mechanisms remain elusive. This study was performed to explore the impact of baicalein on lipid accumulation and inflammatory response in THP-1 macrophage-derived foam cells. Our results showed that baicalein up-regulated the expression of ATP binding cassette transporter A1 (ABCA1), ABCG1, liver X receptor α (LXRα), and peroxisome proliferator-activated receptor γ (PPARγ), promoted cholesterol efflux, and inhibited lipid accumulation. Administration of baicalein also reduced the expression and secretion of TNF-α, IL-1β, and IL-6. Knockdown of LXRα or PPARγ with siRNAs abrogated the effects of baicalein on ABCA1 and ABCG1 expression, cholesterol efflux, lipid accumulation as well as pro-inflammatory cytokine release. In summary, these findings suggest that baicalein exerts a beneficial effect on macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα signaling pathway.
- Journal
- Clin Exp Immunol
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Atherosclerosis
- Paper Title Cn
- Paper Title En
- Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway
- Bilingual Status
- semi_complete