ReferenceID 4626
Inhibitory effects of baicalein against herpes simplex virus type 1
Acta Pharm Sin B
Herpes simplex virus type 1 (HSV-1) is a ubiquitous and widespread human pathogen, which gives rise to a range of diseases, including cold sores, corneal blindness, and encephalitis. Currently, the use of nucleoside anal
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Record Fields
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- Reference Id
- 4626
- Evidence Id
- 21216
- Core Evidence Id
- 21216
- Source Reference Id
- 2520
- Herb2 Reference Id
- HBREF003317
- Subject Paper Key
- HBIN017508_33354504
- Pubmed Id
- 33354504
- Doi
- 10.1016/j.apsb.2020.06.008
- Paper Title
- Inhibitory effects of baicalein against herpes simplex virus type 1
- Paper Abstract
- Herpes simplex virus type 1 (HSV-1) is a ubiquitous and widespread human pathogen, which gives rise to a range of diseases, including cold sores, corneal blindness, and encephalitis. Currently, the use of nucleoside analogs, such as acyclovir and penciclovir, in treating HSV-1 infection often presents limitation due to their side effects and low efficacy for drug-resistance strains. Therefore, new anti-herpetic drugs and strategies should be urgently developed. Here, we reported that baicalein, a naturally derived compound widely used in Asian countries, strongly inhibited HSV-1 replication in several models. Baicalein was effective against the replication of both HSV-1/F and HSV-1/Blue (an acyclovir-resistant strain) in vitro. In the ocular inoculation mice model, baicalein markedly reduced in vivo HSV-1/F replication, receded inflammatory storm and attenuated histological changes in the cornea. Consistently, baicalein was found to reduce the mortality of mice, viral loads both in nose and trigeminal ganglia in HSV-1 intranasal infection model. Moreover, an ex vivo HSV-1-EGFP infection model established in isolated murine epidermal sheets confirmed that baicalein suppressed HSV-1 replication. Further investigations unraveled that dual mechanisms, inactivating viral particles and inhibiting IkappaB kinase beta (IKK-beta) phosphorylation, were involved in the anti-HSV-1 effect of baicalein. Collectively, our findings identified baicalein as a promising therapy candidate against the infection of HSV-1, especially acyclovir-resistant strain.
- Journal
- Acta Pharm Sin B
- Publish Year
- 2020
- Experiment Subject
- mouse; human
- Experiment Type
- Animal Experiment
- Phenotype Related
- Encephalitis; Hsv-1 Infection; Cold Sores; Corneal Blindness; Herpes Simplex Virus Type 1 (hsv-1
- Paper Title Cn
- Paper Title En
- Inhibitory effects of baicalein against herpes simplex virus type 1
- Bilingual Status
- semi_complete