ReferenceID 4620
Aurantio-obtusin improves obesity and insulin resistance induced by high-fat diet in obese mice
Phytother Res
Aurantio-obtusin (AUR) is the main bioactive compound among the anthraquinones, from Cassia seed extract. This study was conducted to identify whether AUR could improve obesity and insulin resistance, induced by a high-f
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Record Fields
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- Reference Id
- 4620
- Evidence Id
- 21210
- Core Evidence Id
- 21210
- Source Reference Id
- 2506
- Herb2 Reference Id
- HBREF003303
- Subject Paper Key
- HBIN017359_32749748
- Pubmed Id
- 32749748
- Doi
- 10.1002/ptr.6805
- Paper Title
- Aurantio-obtusin improves obesity and insulin resistance induced by high-fat diet in obese mice
- Paper Abstract
- Aurantio-obtusin (AUR) is the main bioactive compound among the anthraquinones, from Cassia seed extract. This study was conducted to identify whether AUR could improve obesity and insulin resistance, induced by a high-fat diet in obese mice. Mice were fed a high-fat diet for 6 weeks and were then assigned to the high-fat diet (HFD) control group, the AUR 5 mg/kg group, or the AUR 10 mg/kg group. AUR improves glucose by activating the expression of PI3K, Akt and GLUT4, GLUT2. AUR altered the expression levels of several lipid metabolism-related and adipokine genes. AUR decreased the mRNA expression of PPAR-gamma, FAS and increased the mRNA expression of PPAR-alpha in liver. AUR lowered SREBP-1c, FAS, SCD-1, inflammatory cytokines, and increased the expression of PPAR-gamma, PPAR-alpha, CPT-1, and adiponectin in white adipose tissue (WAT). AUR docking with the insulin receptor showed that the residues of the insulin receptor, ectodomain, were the same as those around the emodin. The effect of AUR may be elicited by regulating the activity of the insulin signaling pathway, expression of lipid metabolism-related genes, and expression of inflammatory cytokine markers to improve adiposity, insulin resistance, and dyslipidemia.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; cassia
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Dyslipidemia; Obese
- Paper Title Cn
- Paper Title En
- Aurantio-obtusin improves obesity and insulin resistance induced by high-fat diet in obese mice
- Bilingual Status
- semi_complete