ReferenceID 4619
Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice
Food Chem Toxicol
Aucubin is pharmacologically active natural compound which possesses numerous beneficial properties. This study aimed to evaluate the protective effect of aucubin against cisplatin (CP)-induced acute kidney injury in mic
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Record Fields
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- Reference Id
- 4619
- Evidence Id
- 21209
- Core Evidence Id
- 21209
- Source Reference Id
- 2503
- Herb2 Reference Id
- HBREF003300
- Subject Paper Key
- HBIN017343_32504734
- Pubmed Id
- 32504734
- Doi
- 10.1016/j.fct.2020.111472
- Paper Title
- Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice
- Paper Abstract
- Aucubin is pharmacologically active natural compound which possesses numerous beneficial properties. This study aimed to evaluate the protective effect of aucubin against cisplatin (CP)-induced acute kidney injury in mice and the mechanism of its action. Aucubin was administrated to mice orally or intraperitoneally (ip) (1.5 and 5 mg/kg) for two consecutive days, two days after ip injection of cisplatin (CP), 11 mg/kg. Treatment with aucubin by both routes of administration ameliorated histopathological changes and reduced elevated serum markers of kidney injury. CP administration increased renal expression of heme oxygenase-1 (HO-1) and 4-hydroxynonenal (4-HNE), as well as tumor necrosis factor-alpha (TNF-alpha), which was dose-dependently ameliorated by aucubin. Moreover, aucubin reduced increased renal expression of cleaved caspase-3 and -9 and decreased poly (ADP-ribose) polymerase (PARP) cleavage. Mechanistically, aucubin suppressed the activation of several signaling pathways involved in inflammation and apoptosis, including nuclear factor-kappa B (NF-kappaB), signal transducer and activator of transcription 3 (STAT3), Akt, extracellular signal-regulated kinase 1/2 (ERK1/2) and forkhead box O3a (FOXO3a). Parenteral application was marginally but statistically more effective in reducing CP-induced kidney injury than oral administration. The findings of this study suggest that aucubin acts as a protective agent against CP-induced nephrotoxicity, which should be further investigated.
- Journal
- Food Chem Toxicol
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cp-induced Kidney Injury; Tumor; Acute Kidney Injury; Kidney Injury
- Paper Title Cn
- Paper Title En
- Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice
- Bilingual Status
- semi_complete