ReferenceID 4580
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
Oxid Med Cell Longev
The use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy. Currently, there are no effective approaches to prevent DOX-related cardiac complications. Asiatic acid (AA) has be
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4580
- Evidence Id
- 21170
- Core Evidence Id
- 21170
- Source Reference Id
- 2427
- Herb2 Reference Id
- HBREF003224
- Subject Paper Key
- HBIN017057_32509145
- Pubmed Id
- 32509145
- Doi
- 10.1155/2020/5347204
- Paper Title
- Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
- Paper Abstract
- The use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy. Currently, there are no effective approaches to prevent DOX-related cardiac complications. Asiatic acid (AA) has been reported to provide cardioprotection against several cardiovascular diseases. However, whether AA could attenuate DOX-related cardiac injury remains unclear. DOX (15 mg/kg) was injected intraperitoneally into the mice to mimic acute cardiac injury, and the mice were given AA (10 mg/kg or 30 mg/kg) for 2 weeks for protection. The data in our study found that AA-treated mice exhibited attenuated cardiac injury and improved cardiac function in response to DOX injection. AA also suppressed myocardial oxidative damage and apoptosis without affecting cardiac inflammation in DOX-treated mice. AA also provided protection in DOX-challenged cardiomyocytes, improved cell viability, and suppressed intracellular reactive oxygen species (ROS) in vitro. Detection of signaling pathways showed that AA activated protein kinase B (AKT) signaling pathway in vivo and in vitro. Furthermore, we found that AA lost its protective effects in the heart with AKT inactivation. In conclusion, our results found that AA could attenuate DOX-induced myocardial oxidative stress and apoptosis via activation of the AKT signaling pathway.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2020
- Experiment Subject
- mouse; dox-challenged cardiomyocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cardiovascular Diseases; Depression Of Cardiac Function; Cardiac Injury; Acute Cardiac Injury; Cardiac Inflammation; Cardiac Complications; Refractory Cardiomyopathy; Attenuated Cardiac Injury
- Paper Title Cn
- Paper Title En
- Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
- Bilingual Status
- semi_complete