ReferenceID 4575
Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice
Int J Mol Sci
The kidney is one of the most susceptible organs to age-related impairments. Generally, renal aging is accompanied by renal fibrosis, which is the final common pathway of chronic kidney diseases. Aristolochic acid (AA),
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Record Fields
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- Reference Id
- 4575
- Evidence Id
- 21165
- Core Evidence Id
- 21165
- Source Reference Id
- 2420
- Herb2 Reference Id
- HBREF003217
- Subject Paper Key
- HBIN016798_34830314
- Pubmed Id
- 34830314
- Doi
- 10.3390/ijms222212432
- Paper Title
- Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice
- Paper Abstract
- The kidney is one of the most susceptible organs to age-related impairments. Generally, renal aging is accompanied by renal fibrosis, which is the final common pathway of chronic kidney diseases. Aristolochic acid (AA), a nephrotoxic agent, causes AA nephropathy (AAN), which is characterized by progressive renal fibrosis and functional decline. Although renal fibrosis is associated with renal aging, whether AA induces renal aging remains unclear. The aim of the present study is to investigate the potential use of AAN as a model of renal aging. Here, we examined senescence-related factors in AAN models by chronically administering AA to C57BL/6 mice. Compared with controls, the AA group demonstrated aging kidney phenotypes, such as renal atrophy, renal functional decline, and tubulointerstitial fibrosis. Additionally, AA promoted cellular senescence specifically in the kidneys, and increased renal p16 mRNA expression and senescence-associated beta-galactosidase activity. Furthermore, AA-treated mice exhibited proximal tubular mitochondrial abnormalities, as well as reactive oxygen species accumulation. Klotho, an antiaging gene, was also significantly decreased in the kidneys of AA-treated mice. Collectively, the results of the present study indicate that AA alters senescence-related factors, and that renal fibrosis is closely related to renal aging.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Renal Functional Decline; Chronic Kidney Diseases; Aa Nephropathy; Proximal Tubular Mitochondrial Abnormalities; Renal Fibrosis; Renal Atrophy; Tubulointerstitial Fibrosis; Renal Aging
- Paper Title Cn
- Paper Title En
- Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice
- Bilingual Status
- semi_complete