ReferenceID 4537
Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease
Chem Biol Interact
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The available drugs improve the symptoms but do not play role in modifying disease effects. Currently, the treatment strategies focus on inhibiting th
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Record Fields
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- Reference Id
- 4537
- Evidence Id
- 21127
- Core Evidence Id
- 21127
- Source Reference Id
- 2350
- Herb2 Reference Id
- HBREF003147
- Subject Paper Key
- HBIN016408_36027948
- Pubmed Id
- 36027948
- Doi
- 10.1016/j.cbi.2022.110120
- Paper Title
- Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease
- Paper Abstract
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The available drugs improve the symptoms but do not play role in modifying disease effects. Currently, the treatment strategies focus on inhibiting the production of Aβ-42 aggregates and tau filaments. In this context the natural plant products could act as a potent candidate. Therefore, we decided to study the effect of apigenin on the transgenic Drosophila model of AD i.e., expressing Aβ-42 in the neurons. The AD flies were allowed to feed on the diet having 25, 50, 75 and 100 μM of apigenin for 30 days. The exposure of AD flies to apigenin showed a dose dependent significant decrease in the oxidative stress and delay in the loss of climbing ability. Apigenin also inhibits the activity of acetylcholinesterase. The immunostaining and molecular docking studies suggest that apigenin inhibits the formation of Aβ-42 aggregates. Apigenin is potent in reducing the AD symptoms being mimicked in the transgenic Drosophila model of AD.
- Journal
- Chem Biol Interact
- Publish Year
- 2022
- Experiment Subject
- drosophila
- Experiment Type
- Animal Experiment
- Phenotype Related
- Neurodegenerative Disorder; Alzheimer's Disease
- Paper Title Cn
- Paper Title En
- Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease
- Bilingual Status
- semi_complete