ReferenceID 4482
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
Oxid Med Cell Longev
Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a furanocoumarin from Angelica dahurica
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Record Fields
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- Reference Id
- 4482
- Evidence Id
- 21072
- Core Evidence Id
- 21072
- Source Reference Id
- 2244
- Herb2 Reference Id
- HBREF003041
- Subject Paper Key
- HBIN015866_32454943
- Pubmed Id
- 32454943
- Doi
- 10.1155/2020/8026838
- Paper Title
- The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
- Paper Abstract
- Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects. However, its potential to ameliorate ALI is unknown. In this study, APAP-treated genetic knockout of Farnesoid X receptor (FXR) and Sirtuin 1 (SIRT1) mice were used for research. The results revealed that IMP could improve the severity of liver injury and inhibit the increase of proinflammatory cytokines, oxidative damage, and apoptosis induced by overdose APAP in an FXR-dependent manner. We also found that IMP enhanced the activation and translocation of FXR by increasing the expression of SIRT1 and the phosphorylation of AMPK. Besides, single administration of IMP at 4 h after APAP injection can also improve necrotic areas and serum transaminase, indicating that IMP have both preventive and therapeutic effects. Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway. These findings suggest that IMP is a potential therapeutic candidate for ALI, offering promise for the treatment of hepatotoxicity associated with APAP overdose.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Acute Liver Injury; Hepatotoxicity; Liver Injury
- Paper Title Cn
- Paper Title En
- The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
- Bilingual Status
- semi_complete