ReferenceID 4460
Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role
Int J Mol Sci
This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpos
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Record Fields
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- Reference Id
- 4460
- Evidence Id
- 21050
- Core Evidence Id
- 21050
- Source Reference Id
- 2207
- Herb2 Reference Id
- HBREF003004
- Subject Paper Key
- HBIN015205_33265949
- Pubmed Id
- 33265949
- Doi
- 10.3390/ijms21239100
- Paper Title
- Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role
- Paper Abstract
- This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpose, we used 36 male Wistar albino rats divided into control rats, rats with MetS and MetS rats treated with 40 mg/kg of DATS every second day for 3 weeks. In the first part, we studied the impact of DATS on MetS control and found that DATS significantly raised H2S, decreased homocysteine and glucose levels and enhanced lipid and antioxidative, while reducing prooxidative parameters. Additionally, this polysulfide improved cardiac function. In the second part, we investigated the impact of DATS on ex vivo induced ischemia/reperfusion (I/R) heart injury and found that DATS consumption significantly improved cardiodynamic parameters and prevented oxidative and histo-architectural variation in the heart. In addition, DATS significantly increased relative gene expression of eNOS, SOD-1 and -2, Bcl-2 and decreased relative gene expression of NF-kappaB, IL-17A, Bax, and caspases-3 and -9. Taken together, the data show that DATS can effectively mitigate MetS and have protective effects against ex vivo induced myocardial I/R injury in MetS rat.
- Journal
- Int J Mol Sci
- Publish Year
- 2020
- Experiment Subject
- rat; garlic
- Experiment Type
- Animal Experiment
- Phenotype Related
- Mets; Metabolic Syndrome; Myocardial I/r Injury
- Paper Title Cn
- Paper Title En
- Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role
- Bilingual Status
- semi_complete