ReferenceID 446
Pregnenolone can protect the brain from cannabis intoxication
Science
Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (mariju
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 446
- Evidence Id
- 17036
- Core Evidence Id
- 17036
- Source Reference Id
- 865
- Herb2 Reference Id
- HBREF001501
- Subject Paper Key
- HBIN040687_24385629
- Pubmed Id
- 24385629
- Doi
- 10.1126/science.1243985
- Paper Title
- Pregnenolone can protect the brain from cannabis intoxication
- Paper Abstract
- Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.
- Journal
- Science
- Publish Year
- 2014
- Experiment Subject
- rats: wistar rats
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Pregnenolone can protect the brain from cannabis intoxication
- Bilingual Status
- semi_complete