ReferenceID 4443
Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice
Eur J Pharmacol
Small GTPase Rab8a is involved in fat-specific protein 27 (Fsp27) mediated lipid droplet accumulation in adipocytes. By screening inhibitors of Rab8a GTPase from a natural compound library, berbamine (BBM), a marketing d
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Record Fields
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- Reference Id
- 4443
- Evidence Id
- 21033
- Core Evidence Id
- 21033
- Source Reference Id
- 2580
- Herb2 Reference Id
- HBREF003377
- Subject Paper Key
- HBIN017888_34982965
- Pubmed Id
- 34982965
- Doi
- 10.1016/j.ejphar.2021.174679
- Paper Title
- Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice
- Paper Abstract
- Small GTPase Rab8a is involved in fat-specific protein 27 (Fsp27) mediated lipid droplet accumulation in adipocytes. By screening inhibitors of Rab8a GTPase from a natural compound library, berbamine (BBM), a marketing drug for treatment of leukopenia in China, was identified to inhibit the activity of Rab8a GTPase and block the differentiation of 3T3-L1 adipocytes. Animal study showed that BBM could reduce body weight, improved glucose and lipid metabolic homeostasis in high-fat diet-induced obesity (DIO) C57BL/6 mice and db/db mice. Additional, BBM increased energy expenditure and inhibited food intake in mice but not in lean mice. Moreover, intracerebroventricular injection (i.c.v.) of BBM inhibited feeding behavior and increased c-Fos expression in paraventricular nucleus of the hypothalamus (PVH) of mice. Our data suggest that BBM may improve obesity through the inhibition of Rab8a GTPase activity and the activation of anorexigenic energy-sensing neuron in PVH.
- Journal
- Eur J Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; 3t3-l1 adipocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Leukopenia; High-fat Diet-induced Obesity
- Paper Title Cn
- Paper Title En
- Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice
- Bilingual Status
- semi_complete