ReferenceID 4432
Antitumor effect of acanthoic acid against primary effusion lymphoma via inhibition of c-FLIP
Phytother Res
Acanthoic acid (AA) is an active substance that is extracted from Croton oblongifolius Roxb., a traditional plant in Thailand. The antiinflammatory effect of AA on NF-kappaB pathway has been exclusively reported, however
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4432
- Evidence Id
- 21022
- Core Evidence Id
- 21022
- Source Reference Id
- 2145
- Herb2 Reference Id
- HBREF002942
- Subject Paper Key
- HBIN014341_34779075
- Pubmed Id
- 34779075
- Doi
- 10.1002/ptr.7322
- Paper Title
- Antitumor effect of acanthoic acid against primary effusion lymphoma via inhibition of c-FLIP
- Paper Abstract
- Acanthoic acid (AA) is an active substance that is extracted from Croton oblongifolius Roxb., a traditional plant in Thailand. The antiinflammatory effect of AA on NF-kappaB pathway has been exclusively reported, however, its anticancer effect is still lacking. PEL is a B cell lymphoma that is mostly found in HIV patients. The prognosis and progression of PEL patients are terribly poor with a median survival time less than 6 months, so the new effective treatment is urgently needed. In this study, we found that AA effectively inhibited PEL cell proliferation with IC50s at 120-130 muM in well-representative cells, while the IC50s of AA in PBMC were higher (>200 muM). AA increased percentages of Annexin V/PI positive cells, whereas adding of caspase inhibitor (Q-VD-OPh) prevented AA-induced cell death. The antiapoptotic protein, c-FLIP, was downregulated by AA which leading to the activation of caspase-8 and -3. Combination of AA and TRAIL dramatically enhanced apoptotic cell death. In PEL xenograft model, AA at the dose of 250 mg/kg effectively inhibited PEL tumor growth without detectable toxicities assessed by mice weight and appearance.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; patient; annexin v/pi positive cells; pel cell; pel xenograft model
- Experiment Type
- Cell Experiment
- Phenotype Related
- Tumor; B Cell Lymphoma
- Paper Title Cn
- Paper Title En
- Antitumor effect of acanthoic acid against primary effusion lymphoma via inhibition of c-FLIP
- Bilingual Status
- semi_complete