ReferenceID 4431
Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice
Int J Mol Sci
We previously demonstrated that acacetin reduces adipogenesis in adipocytes, and decreases lipid accumulation in visceral adipocyte tissue. Here we investigated whether acacetin regulated the mechanisms of lipogenesis an
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4431
- Evidence Id
- 21021
- Core Evidence Id
- 21021
- Source Reference Id
- 2141
- Herb2 Reference Id
- HBREF002938
- Subject Paper Key
- HBIN014294_35563076
- Pubmed Id
- 35563076
- Doi
- 10.3390/ijms23094687
- Paper Title
- Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice
- Paper Abstract
- We previously demonstrated that acacetin reduces adipogenesis in adipocytes, and decreases lipid accumulation in visceral adipocyte tissue. Here we investigated whether acacetin regulated the mechanisms of lipogenesis and inflammation in non-alcoholic fatty liver disease (NAFLD) in obese mice. Male C57BL/6 mice were fed a high-fat diet (HFD), and then administered acacetin by intraperitoneal injection. Acacetin reduced body weight and liver weight in obese mice. Acacetin-treated obese mice exhibited decreased lipid accumulation, increased glycogen accumulation, and improved hepatocyte steatosis. Acacetin regulated triglycerides and total cholesterol in the liver and serum. Acacetin decreased low-density lipoprotein and leptin concentrations, but increased high-density lipoprotein and adiponectin levels in obese mice. Acacetin effectively weakened the gene expressions of transcription factors related to lipogenesis, and promoted the expressions of genes related to lipolysis and fatty acid β-oxidation in liver. Acacetin also reduced expressions of inflammation-related cytokines in the serum and liver. Oleic acid induced lipid accumulation in murine FL83B hepatocytes, and the effects of acacetin treatment indicated that acacetin may regulate lipid metabolism through the AMPK pathway. Acacetin may protect against hepatic steatosis by modulating inflammation and AMPK expression.
- Journal
- Int J Mol Sci
- Publish Year
- 2022
- Experiment Subject
- mouse; murine fl83b hepatocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Hepatic Steatosis; Non-alcoholic Fatty Liver Disease; Hepatocyte Steatosis; Obese
- Paper Title Cn
- Paper Title En
- Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice
- Bilingual Status
- semi_complete