ReferenceID 4410
Scopolin Prevents Adipocyte Differentiation in 3T3-L1 Preadipocytes and Weight Gain in an Ovariectomy-Induced Obese Mouse Model
Int J Mol Sci
Obesity is prevalent in modern human societies. We examined the anti-obesity effects of scopolin on adipocyte differentiation in preadipocyte 3T3-L1 cells and weight loss in an ovariectomy (OVX)-induced obese mouse model
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Record Fields
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- Reference Id
- 4410
- Evidence Id
- 21000
- Core Evidence Id
- 21000
- Source Reference Id
- 2107
- Herb2 Reference Id
- HBREF002904
- Subject Paper Key
- HBIN012506_33218042
- Pubmed Id
- 33218042
- Doi
- 10.3390/ijms21228699
- Paper Title
- Scopolin Prevents Adipocyte Differentiation in 3T3-L1 Preadipocytes and Weight Gain in an Ovariectomy-Induced Obese Mouse Model
- Paper Abstract
- Obesity is prevalent in modern human societies. We examined the anti-obesity effects of scopolin on adipocyte differentiation in preadipocyte 3T3-L1 cells and weight loss in an ovariectomy (OVX)-induced obese mouse model. Scopolin inhibited adipocyte differentiation and lipid accumulation in the preadipocyte cells by suppressing the transcription of adipogenic-related factors, including adiponectin (Adipoq), peroxisome proliferator-activated receptor gamma (Pparg), lipoprotein lipase (Lpl), perilipin1 (Plin1), fatty acid-binding protein 4 (Fabp4), glucose transporter type 4 (Slc2a4), and CCAAT/enhancer-binding protein alpha (Cebpa). In OVX-induced obese mice, administration of scopolin promoted the reduction of body weight, total fat percentage, liver steatosis, and adipose cell size. In addition, the scopolin-treated OVX mice showed decreased serum levels of leptin and insulin. Taken together, these findings suggest that the use of scopolin prevented adipocyte differentiation and weight gain in vitro and in vivo, indicating that scopolin may be a potential bioactive compound for the treatment and prevention of obesity in humans.
- Journal
- Int J Mol Sci
- Publish Year
- 2020
- Experiment Subject
- mouse; human; preadipocyte 3t3-l1 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Ovariectomy; Obese
- Paper Title Cn
- Paper Title En
- Scopolin Prevents Adipocyte Differentiation in 3T3-L1 Preadipocytes and Weight Gain in an Ovariectomy-Induced Obese Mouse Model
- Bilingual Status
- semi_complete