ReferenceID 4402
5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion
Int J Biol Sci
Glioblastoma multiform (GBM) continues to threaten people's lives due to the limited therapeutic strategies. As a new drug, Valerenic Acid suppresses the progression of GBM, however, the mechanism is largely unknown. Her
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 4402
- Evidence Id
- 20992
- Core Evidence Id
- 20992
- Source Reference Id
- 2093
- Herb2 Reference Id
- HBREF002890
- Subject Paper Key
- HBIN012021_32549758
- Pubmed Id
- 32549758
- Doi
- 10.7150/ijbs.44906
- Paper Title
- 5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion
- Paper Abstract
- Glioblastoma multiform (GBM) continues to threaten people's lives due to the limited therapeutic strategies. As a new drug, Valerenic Acid suppresses the progression of GBM, however, the mechanism is largely unknown. Here, we found that Valerenic Acid can inhibit cell proliferation, migration and invasion of GBM cells by increasing innate immune signals such as enhancing ROS levels and activating the AMPK pathway. Inhibition of ROS by N-acetylcysteine (NAC) or attenuation of AMPK by Compound C could block Valerenic Acid-induced cell death. Additionally, the xenograft mouse model also confirmed that Valerenic Acid had anti-tumor effect. Together, our results provide compelling rational to develop Valerenic Acid as an anti-tumor agent against GBM patients.
- Journal
- Int J Biol Sci
- Publish Year
- 2020
- Experiment Subject
- mouse; patient; people
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Glioblastoma Multiform
- Paper Title Cn
- Paper Title En
- 5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion
- Bilingual Status
- semi_complete